α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping.
Angew Chem Int Ed Engl
; 63(2): e202314423, 2024 Jan 08.
Article
em En
| MEDLINE
| ID: mdl-37984884
ABSTRACT
A general and straightforward procedure for the lithiation trapping of cyclic sulfides such as tetrahydrothiophene, tetrahydrothiopyran and a thiomorpholine is described. Trapping with a wide range of electrophiles is demonstrated, leading to more than 50 diverse α-substituted saturated sulfur heterocycles. The methodology provides access to a range of α-substituted cyclic sulfides that are not easily synthesised by the currently available methods.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Reino Unido