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The effects of topical mafenide acetate application on skin graft survival in bacterial contaminated wounds.
Baver Acaban, M; Sari, Alper; Demirbag, Hatice Oruç; Ersöz, Gülden; Aktas, Savas.
Afiliação
  • Baver Acaban M; Plastic, Reconstructive and Aesthetic Surgery Department of Mersin University Medical Faculty, Mersin, Turkey. Electronic address: baveracaban@gmail.com.
  • Sari A; Plastic, Reconstructive and Aesthetic Surgery Department of Mersin University Medical Faculty, Mersin, Turkey.
  • Demirbag HO; Histology and Embryology Department of Mersin University Medical Faculty, Mersin, Turkey.
  • Ersöz G; Infectious Diseases and Clinical Microbiology Department of Mersin University Medical Faculty, Mersin, Turkey.
  • Aktas S; Histology and Embryology Department of Mersin University Medical Faculty, Mersin, Turkey.
Burns ; 50(2): 433-443, 2024 Mar.
Article em En | MEDLINE | ID: mdl-37985270
ABSTRACT

BACKGROUND:

Infection related skin graft loss still remains as a common problem even with the use of systemic antibiotics. Mafenide acetate (Sulfamylon) is a topical antimicrobial agent with a wide spectrum of antimicrobial activity. Since mafenide acetate has the ability to penetrate the burn eschar, it was preferred in the treatment of infected full-thickness skin grafts. We investigated the effects of topical Mafenide acetate application on graft survival in an experimental model of contaminated wound beds in rats. MATERIALS AND

METHODS:

Twenty-eight male Wistar albino rats were included in the study. A full-thickness skin graft (FTSG) was harvested from the back region and the wound bed was inoculated with Pseudomonas aeruginosa. The same FTSG was sutured in place. Rats were divided into 4 groups. In groups 1 and 2, wound care was performed with gauze and hydrofiber dressings respectively. In groups 3 and 4, Mafenide acetate soaked hydrofiber and Mafenide acetate soaked gauze dressings were used respectively. The dressings were closed for 4 days in all groups. The rats in groups 1 and 2 received dressing changes every day. The dressing of the rats in group 3 was changed once every two days. The dressing of the rats in group 4 was changed twice a day.

RESULTS:

In groups 3 and 4, the graft survival rates decreased significantly from day 7 to day 14 in all groups. Histologically, detachment at the dermoepidermal junction, disorganization of collagen along with increased numbers of fibroblasts and a decrease in graft adhesion to the wound bed were determined in Mafenide acetate-treated groups.

CONCLUSION:

In rats treated with Mafenide acetate, graft survival was higher on day 7 and gradually decreased towards day 14. Application of a 2.5% solution of Mafenide acetate longer than 7 days on inoculated skin grafts in a rat model causes significant cytotoxicity and graft loss.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Queimaduras / Mafenida Limite: Animals Idioma: En Revista: Burns Assunto da revista: TRAUMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Queimaduras / Mafenida Limite: Animals Idioma: En Revista: Burns Assunto da revista: TRAUMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article