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The CHANGED Score-A New Tool for the Prediction of Insulin Dependency in Gestational Diabetes.
Rostin, Paul; Balke, Selina; Sroka, Dorota; Fangmann, Laura; Weid, Petra; Henrich, Wolfgang; Königbauer, Josefine Theresia.
Afiliação
  • Rostin P; Department of Obstetrics, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Balke S; Department of Obstetrics, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Sroka D; Department of Obstetrics, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Fangmann L; Department of Obstetrics, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Weid P; Department of Obstetrics, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Henrich W; Department of Obstetrics, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Königbauer JT; Department of Obstetrics, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
J Clin Med ; 12(22)2023 Nov 18.
Article em En | MEDLINE | ID: mdl-38002781
ABSTRACT
Gestational diabetes (GDM) is a frequent complication during pregnancy. We aimed to develop a score to predict future insulin dependency in gestational diabetes (GDM). Data from 1611 patients from Charité Berlins gestational diabetes clinic from 2015 to 2022 were utilized. A stepwise backwards regression, including patient characteristics obtained at the initial presentation, was performed. Predictors examined included age, fasting blood glucose level, blood glucose levels one and two hours after oral glucose tolerance test, pre-pregnancy BMI, number of previous pregnancies and births, and fetal sex. The ideal cutoff value between high and low risk for insulin dependency was assessed and the score was internally validated. There were 1249 (77.5%) women diagnosed with dietary GDM and 362 (22.5%) were diagnosed with insulin-dependent GDM. The CHarité AssessmeNt of GEstational Diabetes (CHANGED) Score achieved an area under the curve of 0.77 (95% confidence interval 0.75-0.80; 0.75 in internal validation). The optimal cutoff value was calculated at a score value of 9 (72% sensitivity, 69% specificity). We developed an easily applicable tool to accurately predict insulin dependency in gestational diabetes. The CHANGED Score is routinely available and can potentially improve maternal and fetal outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha
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