Clec7a drives gut fungus-mediated host lipid deposition.
Microbiome
; 11(1): 264, 2023 Nov 25.
Article
em En
| MEDLINE
| ID: mdl-38007451
ABSTRACT
BACKGROUND:
Compared to that of bacteria, the role of gut fungi in obesity development remains unknown.RESULTS:
Here, alterations in gut fungal biodiversity and composition were confirmed in obese pig models and high-fat diet (HFD)-fed mice. Antifungal drugs improved diet-induced obesity, while fungal reconstruction by cohousing or fecal microbiota transplantation maintained the obese phenotype in HFD-fed mice. Fungal profiling identified 5 fungal species associated with obesity. Specifically, Ascomycota_sp. and Microascaceae_sp. were reduced in obese mice and negatively correlated with fat content. Oral supplementation with fungi was sufficient to prevent and treat diet-induced obesity. Clec7a, which is involved in fungal recognition, was highly expressed in HFD-fed mice. The Clec7a agonist accelerated diet-induced obesity, while Clec7a deficieny in mice resulted in resistance to diet-induced obesity and blocked the anti-obese effect of antifungal drugs and fungi.CONCLUSIONS:
Taken together, these results indicate that gut fungi/Clec7a signaling is involved in diet-induced obesity and may have therapeutic implications as a biomarker for metabolic dysregulation in humans. Video Abstract.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antifúngicos
/
Obesidade
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Microbiome
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China