A highly selective ratio-metric fluorescent sensor for visualizing nitroreductase in hypoxic cells.

Xu, Yumei; Hu, Bing; Cui, Yanjun; Li, Li; Nian, Fang; Zhang, Zhixia; Wang, Wenting

Xu, Yumei; Hu, Bing; Cui, Yanjun; Li, Li; Nian, Fang; Zhang, Zhixia; Wang, Wenting.

Afiliação

Xu Y; Institute of Agricultural Resources Chemistry and Application, College of Science, Gansu Agriculture University, No. 1 Yingmen village, Anning District, Lanzhou, Gansu 730070, China. xuym@gsau.edu.cn.
Hu B; Institute of Agricultural Resources Chemistry and Application, College of Science, Gansu Agriculture University, No. 1 Yingmen village, Anning District, Lanzhou, Gansu 730070, China. xuym@gsau.edu.cn.
Cui Y; Institute of Agricultural Resources Chemistry and Application, College of Science, Gansu Agriculture University, No. 1 Yingmen village, Anning District, Lanzhou, Gansu 730070, China. xuym@gsau.edu.cn.
Li L; Institute of Agricultural Resources Chemistry and Application, College of Science, Gansu Agriculture University, No. 1 Yingmen village, Anning District, Lanzhou, Gansu 730070, China. xuym@gsau.edu.cn.
Nian F; Institute of Agricultural Resources Chemistry and Application, College of Science, Gansu Agriculture University, No. 1 Yingmen village, Anning District, Lanzhou, Gansu 730070, China. xuym@gsau.edu.cn.
Zhang Z; Institute of Agricultural Resources Chemistry and Application, College of Science, Gansu Agriculture University, No. 1 Yingmen village, Anning District, Lanzhou, Gansu 730070, China. xuym@gsau.edu.cn.
Wang W; College of Life and Health, Wuhan Vocational College of Software and Engineering, Wuhan 430205, China.

Chem Commun (Camb) ; 60(1): 83-86, 2023 Dec 19.

Article em En | MEDLINE | ID: mdl-38018699

RESUMO

Herein, we have developed a novel single-molecular probe (NORP) for selective and accurate determination of NTR in living cells. It was discovered that up-regulation of endogenous NTR occurred in response to hypoxic stimulation, and there was a dependence between the NTR levels and the degree of hypoxia.

Assuntos

Corantes Fluorescentes; Hipóxia; Humanos; Sondas Moleculares; Nitrorredutases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Corantes Fluorescentes / Hipóxia Limite: Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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