Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones.
JACS Au
; 3(11): 2981-2986, 2023 Nov 27.
Article
em En
| MEDLINE
| ID: mdl-38034968
ABSTRACT
Based on an amino-group-assisted coordination strategy and a proton-shuttle-activated outer-sphere mode, the cobalt-catalyzed asymmetric hydrogenation of α-primary amino ketones has been developed, resulting in the efficient synthesis of chiral vicinal amino alcohols bearing functionalized aryl rings in high yields and enantioselectivities (up to 99% enantiomeric excess (ee)) within 0.5 h.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
JACS Au
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China