The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression of <i>C-MYC</i>.

Aoki, Yusuke; Kubota, Yutaro; Han, Qinghong; Masaki, Noriyuki; Obara, Koya; Bouvet, Michael; Chawla, Sant P; Tome, Yasunori; Nishida, Kotaro; Hoffman, Robert M

The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression of C-MYC.

Aoki, Yusuke; Kubota, Yutaro; Han, Qinghong; Masaki, Noriyuki; Obara, Koya; Bouvet, Michael; Chawla, Sant P; Tome, Yasunori; Nishida, Kotaro; Hoffman, Robert M.

Afiliação

Aoki Y; AntiCancer Inc, San Diego, CA, U.S.A.; yaoki0630@gmail.com.
Kubota Y; Department of Surgery, University of California, San Diego, CA, U.S.A.
Han Q; Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Masaki N; AntiCancer Inc, San Diego, CA, U.S.A.
Obara K; Department of Surgery, University of California, San Diego, CA, U.S.A.
Bouvet M; AntiCancer Inc, San Diego, CA, U.S.A.
Chawla SP; AntiCancer Inc, San Diego, CA, U.S.A.
Tome Y; Department of Surgery, University of California, San Diego, CA, U.S.A.
Nishida K; AntiCancer Inc, San Diego, CA, U.S.A.
Hoffman RM; Department of Surgery, University of California, San Diego, CA, U.S.A.

Cancer Genomics Proteomics ; 20(6suppl): 679-685, 2023 Dec.

Article em En | MEDLINE | ID: mdl-38035708

Assuntos

Neoplasias Ósseas; Osteossarcoma; Humanos; Neoplasias Ósseas/tratamento farmacológico; Etionina/uso terapêutico; Metionina/metabolismo; Osteossarcoma/tratamento farmacológico; Osteossarcoma/patologia; Racemetionina; Proteínas Recombinantes/uso terapêutico

Palavras-chave

Hoffman effect; Methioninase; c-MYC; down-regulation; eradication; ethionine; methionine addiction; osteosarcoma; synergy

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma Limite: Humans Idioma: En Revista: Cancer Genomics Proteomics Assunto da revista: BIOQUIMICA / GENETICA MEDICA / NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article País de publicação: Grécia

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google