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The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells.
Koh, Gene Ching Chiek; Boushaki, Soraya; Zhao, Salome Jingchen; Pregnall, Andrew Marcel; Sadiyah, Firas; Badja, Cherif; Memari, Yasin; Georgakopoulos-Soares, Ilias; Nik-Zainal, Serena.
Afiliação
  • Koh GCC; Department of Oncology, Early Cancer Institute, University of Cambridge, Cambridge, UK.
  • Boushaki S; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Zhao SJ; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Pregnall AM; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Sadiyah F; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Badja C; Department of Oncology, Early Cancer Institute, University of Cambridge, Cambridge, UK.
  • Memari Y; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Georgakopoulos-Soares I; Department of Oncology, Early Cancer Institute, University of Cambridge, Cambridge, UK.
  • Nik-Zainal S; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Nat Genet ; 56(1): 23-26, 2024 Jan.
Article em En | MEDLINE | ID: mdl-38036782
ABSTRACT
The chemotherapeutic agent CX-5461, or pidnarulex, has been fast-tracked by the United States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2- and PALB2-mutated cancers. It is under investigation in phase I and II trials. Here, we find that, although CX-5461 exhibits synthetic lethality in BRCA1-/BRCA2-deficient cells, it also causes extensive, nonselective, collateral mutagenesis in all three cell lines tested, to magnitudes that exceed known environmental carcinogens.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênicos / Neoplasias Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênicos / Neoplasias Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido