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Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis.
Pandey, Sushil; Vilchèze, Catherine; Werngren, Jim; Bainomugisa, Arnold; Mansjö, Mikael; Groenheit, Ramona; Miotto, Paolo; Cirillo, Daniela M; Coulter, Christopher; Baulard, Alain R; Schön, Thomas; Jacobs, William R; Djaout, Kamel; Köser, Claudio U.
Afiliação
  • Pandey S; Queensland Mycobacterium Reference Laboratory, Pathology Queensland , Brisbane, Queensland, Australia.
  • Vilchèze C; Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York, USA.
  • Werngren J; Public Health Agency of Sweden , Solna, Sweden.
  • Bainomugisa A; Queensland Mycobacterium Reference Laboratory, Pathology Queensland , Brisbane, Queensland, Australia.
  • Mansjö M; Public Health Agency of Sweden , Solna, Sweden.
  • Groenheit R; Public Health Agency of Sweden , Solna, Sweden.
  • Miotto P; Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute , Milan, Italy.
  • Cirillo DM; Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute , Milan, Italy.
  • Coulter C; Queensland Mycobacterium Reference Laboratory, Pathology Queensland , Brisbane, Queensland, Australia.
  • Baulard AR; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - Center for Infection and Immunity of Lille , Lille, France.
  • Schön T; Department of Infectious Diseases, Linköping University Hospital , Linköping, Sweden.
  • Jacobs WR; Division of Infection and Inflammation, Institute of Biomedical and Clinical Sciences, Linköping University , Linköping, Sweden.
  • Djaout K; Department of Infectious Diseases, Region Östergötland and Kalmar County Hospital, Linköping University , Linköping, Sweden.
  • Köser CU; Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York, USA.
Antimicrob Agents Chemother ; 68(1): e0109623, 2024 Jan 10.
Article em En | MEDLINE | ID: mdl-38038476
ABSTRACT
Results from clinical strains and knockouts of the H37Rv and CDC1551 laboratory strains demonstrated that ndh (Rv1854c) is not a resistance-conferring gene for isoniazid, ethionamide, delamanid, or pretomanid in Mycobacterium tuberculosis. This difference in the susceptibility to NAD-adduct-forming drugs compared with other mycobacteria may be driven by differences in the absolute intrabacterial NADH concentration.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália