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Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank.
Lai, Dongbing; Kuo, Sally I-Chun; Wetherill, Leah; Aliev, Fazil; Zhang, Michael; Marco, Abreu; Schwantes-An, Tae-Hwi; Dick, Danielle; Francis, Meredith W; Johnson, Emma C; Kamarajan, Chella; Kinreich, Sivan; Kuperman, Samuel; Meyers, Jacquelyn; Nurnberger, John I; Liu, Yunlong; Edenberg, Howard J; Porjesz, Bernice; Agrawal, Arpana; Foroud, Tatiana; Schuckit, Marc; Plawecki, Martin H; Bucholz, Kathleen K; McCutcheon, Vivia V.
Afiliação
  • Lai D; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Kuo SI; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
  • Wetherill L; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Aliev F; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
  • Zhang M; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Marco A; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Schwantes-An TH; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Dick D; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
  • Francis MW; School of Social Work, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Johnson EC; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Kamarajan C; Henri Begleiter Neurodynamics Lab, Department of Psychiatry, SUNY Downstate Health Science University, New York, New York, USA.
  • Kinreich S; Henri Begleiter Neurodynamics Lab, Department of Psychiatry, SUNY Downstate Health Science University, New York, New York, USA.
  • Kuperman S; Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
  • Meyers J; Henri Begleiter Neurodynamics Lab, Department of Psychiatry, SUNY Downstate Health Science University, New York, New York, USA.
  • Nurnberger JI; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Liu Y; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Edenberg HJ; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Porjesz B; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Agrawal A; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Foroud T; Henri Begleiter Neurodynamics Lab, Department of Psychiatry, SUNY Downstate Health Science University, New York, New York, USA.
  • Schuckit M; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Plawecki MH; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Bucholz KK; Department of Psychiatry, University of California, San Diego Medical School, San Diego, California, USA.
  • McCutcheon VV; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Alcohol Clin Exp Res (Hoboken) ; 48(2): 283-294, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38054532
ABSTRACT

BACKGROUND:

In the United States, ~50% of individuals who meet criteria for alcohol use disorder (AUD) during their lifetimes do not remit. We previously reported that a polygenic score for AUD (PGSAUD ) was positively associated with AUD severity as measured by DSM-5 lifetime criterion count, and AUD severity was negatively associated with remission. Thus, we hypothesized that PGSAUD would be negatively associated with remission.

METHODS:

Individuals of European (EA) and African ancestry (AA) from the Collaborative Study on the Genetics of Alcoholism (COGA) who met lifetime criteria for AUD, and two EA cohorts ascertained for studies of liver diseases and substance use disorders from the Indiana Biobank were included. In COGA, 12-month remission was defined as any period of ≥12 consecutive months without meeting AUD criteria except craving and was further categorized as abstinent and non-abstinent. In the Indiana Biobank, remission was defined based on ICD codes and could not be further distinguished as abstinent or non-abstinent. Sex and age were included as covariates. COGA analyses included additional adjustment for AUD severity, family history of remission, and AUD treatment history.

RESULTS:

In COGA EA, PGSAUD was negatively associated with 12-month and non-abstinent remission (p ≤ 0.013, ßs between -0.15 and -0.10) after adjusting for all covariates. In contrast to the COGA findings, PGSAUD was positively associated with remission (p = 0.004, ß = 0.28) in the Indiana Biobank liver diseases cohort but not in the Indiana Biobank substance use disorder cohort (p = 0.17, ß = 0.15).

CONCLUSIONS:

PGSAUD was negatively associated with 12-month and non-abstinent remission in COGA EA, independent of behavioral measures of AUD severity and family history of remission. The discrepant results in COGA and the Indiana Biobank could reflect different ascertainment strategies the Indiana Biobank participants were older and had higher rates of liver disease, suggesting that these individuals remitted due to alcohol-related health conditions that manifested in later life.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Alcohol Clin Exp Res (Hoboken) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Alcohol Clin Exp Res (Hoboken) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos