Topical applications of heterologous platelet rich plasma (PRP) for refractory gingival lesions in autoimmune blistering diseases.
Ital J Dermatol Venerol
; 159(1): 55-59, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38059779
ABSTRACT
BACKGROUND:
Recalcitrant gingival erosions, blisters and desquamative gingivitis are common features in oral autoimmune blistering diseases (AIBD). First line treatments include high-dosage corticosteroids and other immunosuppressive drugs, with several side effects and elevated number of recurrences. Autologous platelet-rich plasma (PRP) has been recently introduced as an alternative treatment and its use seems to be promising and safe.METHODS:
In this study we describe the use of topical application of heterologous PRP in nine patients affected by mucous membrane pemphigoid, with gingival lesions refractory to previous treatments. Topical applications of PRP were performed once a week for 2 months and the endpoint for clinical evaluation was set 3 months after the last session. Oral disease severity score (ODSS) and VAS scores for pain measurement were recorded before and after treatment.RESULTS:
The procedure was painless, well accepted, and free from adverse reactions. All patients (100%) reported a reduction in VAS whereas reduction in ODSS was observed in 89% of patients.CONCLUSIONS:
Within the limits of the study, topical heterologous PRP is a safe and promising procedure to be studied in future controlled randomized trials as adjuvant treatment for refractory gingival lesions in patients with AIBDs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Penfigoide Mucomembranoso Benigno
/
Plasma Rico em Plaquetas
/
Gengivite
/
Doenças da Boca
Limite:
Humans
Idioma:
En
Revista:
Ital J Dermatol Venerol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália