[Research progress on the effect of chemical environmental pollutant exposure on mitochondrial DNA damage].

ABSTRACT

People are exposed to a variety of different harmful factors through their daily life, diet, and occupational environment, and exposure to these dangerous factors results in varying degrees of damage to the organism. The damage to mitochondria from exposure to chemical harmful factors in environment is of increasing concern. The integrity of the mitochondrial genome is critical for mitochondrial function and cellular homeostasis, and mitochondria are susceptible to damage and mitochondrial dysfunction when stimulated by various harmful chemical environmental factors. It has been shown that exposure to a variety of chemical pollutants can produce varying degrees of damage to mitochondria, and these pollutants may cause mitochondrial structural and functional disorders by inducing oxidative stress, including impaired electron respiratory chain transmission, alterations in mitochondrial membrane potential, mitochondrial DNA mutations/deletions, and mitochondrial DNA copy number variation. Mitochondrial damage can further lead to abnormal cell function, apoptosis, and death, which induce related diseases. Therefore, this paper provides a review of the role of chemical factor exposure in the environment, such as heavy metals, on mitochondrial damage.