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Research on the application of Thelephora ganbajun exopolysaccharides in antioxidant, anti-inflammatory and spot-fading cosmetics.
Zheng, Lan; Yang, Furui; Liang, Jie; Zhao, Yonglei; Niu, Junhua; Ma, Yaohong; Meng, Qingjun; Liu, Qingai; Gong, Weili; Wang, Binglian.
Afiliação
  • Zheng L; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China. Electronic address: zhenglan24@163.com.
  • Yang F; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Liang J; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Zhao Y; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Niu J; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Ma Y; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China. Electronic address: mayaohong@126.com.
  • Meng Q; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Liu Q; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Gong W; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Wang B; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Int J Biol Macromol ; 257(Pt 2): 128713, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38081489
ABSTRACT
Thelephora ganbajun exopolysaccharides (TGEP) with a "coral-like" branched chain structure (main chain diameter âˆ¼ 80 nm) were prepared by liquid fermentation and fractionated by ion-exchange chromatography. The main fraction (TGEP-2) with the highest in vitro antioxidant capacity was composed of Glc, Man, Gal, GalA, GlcA, Ara, Rha, GlcN, Fuc and Rib in a molar ratio of 465.43420.43219.14188.433735.1431.4319.4311.141, with a molecular weight of 1.879 × 104 Da. The sequence of monosaccharide residue release revealed that Gal, Glc and Ara residues were more distributed in the side-branch chains and at their ends, whereas Man and GalA residues were more distributed in the main chains. TGEP-2 contained linear residues (mainly →4)-Glcp-(1 â†’ and →4)-Manp-(1→), branch residues (→3,6)-Glcp-(1→, →4,6)-Glcp-(1 â†’ and →3,6)-Galp-(1→) and terminal residues (Galp-(1→, Manp-(1 â†’ and Glcp-(1→). TGEP-2 consisted of α- and ß-glycosidically linked pyranosides, with a triple helical conformation and many long branches. Zebrafish oxidative stress and inflammation models found that TGEP-2 had antioxidant and anti-inflammatory activities. The zebrafish skin black spot assay showed that TGEP-2 inhibited melanin formation. Therefore, extracellular polysaccharides of T. ganbajun have strong application potential in anti-oxidant, anti-inflammatory and skin spot-fading functions cosmetics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Basidiomycota / Peixe-Zebra / Antioxidantes Limite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2024 Tipo de documento: Article País de publicação: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Basidiomycota / Peixe-Zebra / Antioxidantes Limite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2024 Tipo de documento: Article País de publicação: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS