NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms.

Gerstberger, Stefanie; Ganesh, Karuna

Gerstberger, Stefanie; Ganesh, Karuna.

Afiliação

Gerstberger S; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ganesh K; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Molecular Pharmacology Program, Sloan Kettering Institute, New York, NY 10065, USA. Electronic address: ganeshk@mskcc.org.

Cancer Cell ; 41(12): 2014-2016, 2023 12 11.

Article em En | MEDLINE | ID: mdl-38086333

RESUMO

Neuroendocrine neoplasms are rare cancers with limited treatment options and preclinical models. In this issue of Cancer Cell, Dayton et al. establish a patient-derived tumor organoid biobank encompassing pulmonary low-grade neuroendocrine tumors (LNETs) and high-grade neuroendocrine carcinomas (LCNECs), identifying novel biomarker-dependent therapeutic vulnerabilities using niche perturbation and drug response assays.

Assuntos

Carcinoma Neuroendócrino; Neoplasias Pulmonares; Tumores Neuroendócrinos; Humanos; Bancos de Espécimes Biológicos; Tumores Neuroendócrinos/tratamento farmacológico; Tumores Neuroendócrinos/genética; Tumores Neuroendócrinos/patologia; Neoplasias Pulmonares/patologia; Carcinoma Neuroendócrino/tratamento farmacológico; Carcinoma Neuroendócrino/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumores Neuroendócrinos / Carcinoma Neuroendócrino / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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