Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation.

Zheng, Lufeng; Zou, Yunting; Xie, Tianyuan; Wu, Xiuyuan; Tan, Yuchen; Mei, Shuang; Geng, Yifei; Chen, Shutong; Xu, Shengtao; Niu, Miao-Miao

Zheng, Lufeng; Zou, Yunting; Xie, Tianyuan; Wu, Xiuyuan; Tan, Yuchen; Mei, Shuang; Geng, Yifei; Chen, Shutong; Xu, Shengtao; Niu, Miao-Miao.

Afiliação

Zheng L; School of Life Science and Technology, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 211198, China.
Zou Y; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 211198, China.
Xie T; School of Life Science and Technology, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 211198, China.
Wu X; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
Tan Y; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
Mei S; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 211198, China.
Geng Y; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 211198, China.
Chen S; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 211198, China.
Xu S; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
Niu MM; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 211198, China.

J Med Chem ; 66(23): 16187-16200, 2023 12 14.

Article em En | MEDLINE | ID: mdl-38093696

Assuntos

Antineoplásicos; Tubulina (Proteína); Humanos; Linhagem Celular Tumoral; Tubulina (Proteína)/metabolismo; Neuropilina-1; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Antineoplásicos/química; Ensaios de Seleção de Medicamentos Antitumorais; Apoptose; Farmacóforo; Proliferação de Células; Pontos de Checagem da Fase G2 do Ciclo Celular; Moduladores de Tubulina/farmacologia; Moduladores de Tubulina/uso terapêutico; Moduladores de Tubulina/química; Polimerização; Relação Estrutura-Atividade

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tubulina (Proteína) / Antineoplásicos Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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