A Chemical Counterpart to the Resolution Step of Nature's Intein-Mediated Protein Splicing.
ACS Chem Biol
; 19(1): 9-14, 2024 Jan 19.
Article
em En
| MEDLINE
| ID: mdl-38096499
ABSTRACT
In the course of an attempted total chemical synthesis of the ant insulin-like peptide-2 (ILP2) protein molecule, specific cleavage of a backbone peptide bond in a branched ester-linked polypeptide chain with concomitant peptide splicing was observed. The side reaction was investigated in model compounds. Here, we postulate a chemical mechanism for this novel polypeptide backbone cleavage reaction as a chemical counterpart to the resolution step of biochemical intein-mediated protein splicing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Processamento de Proteína
/
Inteínas
Idioma:
En
Revista:
ACS Chem Biol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos