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Quantitative metrics of the LV trabeculated layer by cardiac CT and cardiac MRI in patients with suspected noncompaction cardiomyopathy.
Manohar, Ashish; Vigneault, Davis M; Kwon, Deborah H; Caliskan, Kadir; Budde, Ricardo P J; Hirsch, Alexander; Lee, Seung-Pyo; Lee, Whal; Owens, Anjali; Litt, Harold; Haddad, Francois; Mistelbauer, Gabriel; Wheeler, Matthew; Rubin, Daniel; Tang, W H Wilson; Nieman, Koen.
Afiliação
  • Manohar A; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA. ashman@stanford.edu.
  • Vigneault DM; Department of Radiology, Stanford University, Stanford, CA, USA. ashman@stanford.edu.
  • Kwon DH; Cardiovascular Institute, Stanford University, Stanford, CA, USA. ashman@stanford.edu.
  • Caliskan K; Department of Radiology, Stanford University, Stanford, CA, USA.
  • Budde RPJ; Department of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Hirsch A; Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Lee SP; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Lee W; Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Owens A; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Litt H; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
  • Haddad F; Department of Radiology, Seoul National University Hospital, Seoul, South Korea.
  • Mistelbauer G; Department of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, PA, USA.
  • Wheeler M; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
  • Rubin D; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
  • Tang WHW; Cardiovascular Institute, Stanford University, Stanford, CA, USA.
  • Nieman K; Department of Radiology, Stanford University, Stanford, CA, USA.
Eur Radiol ; 34(7): 4261-4272, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38114847
ABSTRACT

OBJECTIVES:

To compare cardiac computed tomography (CCT) and cardiac magnetic resonance (CMR) for the quantitative assessment of the left ventricular (LV) trabeculated layer in patients with suspected noncompaction cardiomyopathy (NCCM). MATERIALS AND

METHODS:

Subjects with LV excessive trabeculation who underwent both CMR and CCT imaging as part of the prospective international multicenter NONCOMPACT clinical study were included. For each subject, short-axis CCT and CMR slices were matched. Four quantitative metrics were estimated 1D noncompacted-to-compacted ratio (NCC), trabecular-to-myocardial area ratio (TMA), trabecular-to-endocardial cavity area ratio (TCA), and trabecular-to-myocardial volume ratio (TMV). In 20 subjects, end-diastolic and mid-diastolic CCT images were compared for the quantification of the trabeculated layer. Relationships between the metrics were investigated using linear regression models and Bland-Altman analyses.

RESULTS:

Forty-eight subjects (49.9 ± 12.8 years; 28 female) were included in this study. NCC was moderately correlated (r = 0.62), TMA and TMV were strongly correlated (r = 0.78 and 0.78), and TCA had excellent correlation (r = 0.92) between CMR and CCT, with an underestimation bias from CCT of 0.3 units, and 5.1, 4.8, and 5.4 percent-points for the 4 metrics, respectively. TMA, TCA, and TMV had excellent correlations (r = 0.93, 0.96, 0.94) and low biases (- 3.8, 0.8, - 3.8 percent-points) between the end-diastolic and mid-diastolic CCT images.

CONCLUSIONS:

TMA, TCA, and TMV metrics of the LV trabeculated layer in patients with suspected NCCM demonstrated high concordance between CCT and CMR images. TMA and TCA were highly reproducible and demonstrated minimal differences between mid-diastolic and end-diastolic CCT images. CLINICAL RELEVANCE STATEMENT The results indicate similarity of CCT to CMR for quantifying the LV trabeculated layer, and the small differences in quantification between end-diastole and mid-diastole demonstrate the potential for quantifying the LV trabeculated layer from clinically performed coronary CT angiograms. KEY POINTS • Data on cardiac CT for quantifying the left ventricular trabeculated layer are limited. • Cardiac CT yielded highly reproducible metrics of the left ventricular trabeculated layer that correlated well with metrics defined by cardiac MR. • Cardiac CT appears to be equivalent to cardiac MR for the quantification of the left ventricular trabeculated layer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Tomografia Computadorizada por Raios X / Ventrículos do Coração Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Radiol Assunto da revista: RADIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Tomografia Computadorizada por Raios X / Ventrículos do Coração Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Radiol Assunto da revista: RADIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos