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Unveiling the Psychedelic Journey: An Appraisal of Psilocybin as a Profound Antidepressant Therapy.
Shah, Fatima Iftikhar; Shehzadi, Somia; Akram, Fatima; Haq, Ikram Ul; Javed, Benish; Sabir, Sadeed; Kazim, Yasha; Ashfaq, Sehrish.
Afiliação
  • Shah FI; The University of Lahore, Lahore, Pakistan.
  • Shehzadi S; The University of Lahore, Lahore, Pakistan.
  • Akram F; Institute of Industrial Biotechnology, Government College University, Lahore, 54000, Pakistan. fatima_iib@yahoo.com.
  • Haq IU; Institute of Industrial Biotechnology, Government College University, Lahore, 54000, Pakistan.
  • Javed B; The University of Lahore, Lahore, Pakistan.
  • Sabir S; The University of Lahore, Lahore, Pakistan.
  • Kazim Y; The University of Lahore, Lahore, Pakistan.
  • Ashfaq S; The University of Lahore, Lahore, Pakistan.
Mol Biotechnol ; 2023 Dec 20.
Article em En | MEDLINE | ID: mdl-38117395
ABSTRACT
Depression, a global health concern with significant implications for suicide rates, remains challenging to treat effectively with conventional pharmacological options. The existing pharmaceutical interventions for these illnesses need daily dosing, are accompanied by various adverse effects, and may exhibit limited efficacy in certain cases. However, hope emerges from an unlikely source-Psilocybin, a natural hallucinogen found in certain mushrooms. Recently, this enigmatic compound has garnered attention for its potential therapeutic benefits in addressing various mental health issues, including depression. Psilocybin alters mood, cognition, and perception by acting on a particular subtype of serotonin receptors in the brain. It's feasible that these shifts in consciousness will promote healing development, offering a novel approach to depression management. This comprehensive review explores psilocybin, derived from specific mushrooms, and its implications in the treatment of depression. The study examines new perspectives and therapeutic possibilities surrounding psilocybin, addressing existing gaps in academic literature. It delves into its biosynthesis, unique mechanisms of action, therapeutic applications, and anti-depressive effects. By uncovering the potential of this mind-altering substance, the review aims to advance psychiatric care, offering hope to those globally affected by depression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Biotechnol Assunto da revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Paquistão País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Biotechnol Assunto da revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Paquistão País de publicação: Suíça