RUNX1 methylation as a cancer biomarker in differentiating papillary thyroid cancer from benign thyroid nodules.
Epigenomics
; 15(23): 1257-1272, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-38126720
ABSTRACT
Aim:
It remains a challenge to accurately identify malignancy of thyroid nodules when biopsy is indeterminate. The authors aimed to investigate the abnormal DNA methylation signatures in papillary thyroid cancer (PTC) compared with benign thyroid nodules (BTNs).Methods:
The authors performed genome profiling by 850K array and RNA sequencing in early-stage PTC and BTN tissue samples. The identified gene was validated in two independent case-control studies using mass spectrometry.Results:
Hypomethylation of RUNX1 in PTC was identified and verified (all odds ratios ≥1.50). RUNX1 methylation achieved good accuracy in differentiating early-stage PTC from BTNs, especially for younger women.Conclusion:
The authors disclosed a significant association between RUNX1 hypomethylation and PTC, suggesting RUNX1 methylation as a potential biomarker for companion diagnosis of malignant thyroid nodules.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
/
Biomarcadores Tumorais
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Nódulo da Glândula Tireoide
/
Subunidade alfa 2 de Fator de Ligação ao Core
Limite:
Female
/
Humans
Idioma:
En
Revista:
Epigenomics
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China