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Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities.
Zang, Wei-Biao; Wei, Hui-Ling; Zhang, Wei-Wei; Ma, Wei; Li, Juan; Yao, Yao.
Afiliação
  • Zang WB; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
  • Wei HL; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China.
  • Zhang WW; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China.
  • Ma W; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China.
  • Li J; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China; Ningxia Engineering and Technology Research Center for Modernization of Characteristic Chinese Medicine, and Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, 75
  • Yao Y; School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China. Electronic address: 20070007@nxmu.edu.cn.
Eur J Med Chem ; 265: 116070, 2024 Feb 05.
Article em En | MEDLINE | ID: mdl-38134747
ABSTRACT
Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly. Contemporary treatments can only relieve symptoms but fail to delay disease progression. Curcumin is a naturally derived compound that has demonstrated significant therapeutic effects in AD treatment. Recently, molecular hybridization has been utilized to combine the pharmacophoric groups present in curcumin with those of other AD drugs, resulting in a series of novel compounds that enhance the therapeutic efficacy through multiple mechanisms. In this review, we firstly provide a concise summary of various pathogenetic hypotheses of AD and the mechanism of action of curcumin in AD, as well as the concept of molecular hybridization. Subsequently, we focus on the recent development of hybrid molecules derived from curcumin, summarizing their structures and pharmacological activities, including cholinesterase inhibitory activity, Aß aggregation inhibitory activity, antioxidant activity, and other activities. The structure-activity relationships were further discussed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Curcumina / Doença de Alzheimer Limite: Aged / Humans Idioma: En Revista: Eur J Med Chem / Eur. j. med. chem / European journal of medicinal chemistry Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Curcumina / Doença de Alzheimer Limite: Aged / Humans Idioma: En Revista: Eur J Med Chem / Eur. j. med. chem / European journal of medicinal chemistry Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: França