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Differences in HCV Seroprevalence, Clinical Features, and Treatment Outcomes between Female and Male Incarcerated Population: Results from a Matched Cohort Study.
Fiore, Vito; De Vito, Andrea; Rastrelli, Elena; Manca, Valentina; De Matteis, Giuseppe; Ranieri, Roberto; Pontali, Emanuele; Geremia, Nicholas; Panese, Sandro; Starnini, Giulio; Madeddu, Giordano; Babudieri, Sergio.
Afiliação
  • Fiore V; Unit of Infectious Diseases, Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.
  • De Vito A; Unit of Infectious Diseases, Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.
  • Rastrelli E; PhD School in Biomedical Science, Biomedical Science Department, University of Sassari, 07100 Sassari, Italy.
  • Manca V; Medicina Protetta-Unit of Infectious Diseases, Belcolle Hospital, 01100 Viterbo, Italy.
  • De Matteis G; Unit of Infectious Diseases, Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.
  • Ranieri R; Health Protection for Adults and Youth Unit, Penitentiary Institute, 84124 Salerno, Italy.
  • Pontali E; Penitentiary Infectious Diseases Unit, A.O. Santi Paolo e Carlo, University of Milan, 20122 Milan, Italy.
  • Geremia N; Infectious Disease Unit, Galliera Hospital, 16128 Genoa, Italy.
  • Panese S; Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale Dell'Angelo, 30174 Venice, Italy.
  • Starnini G; Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale Civile "S.S. Giovanni e Paolo", 30122 Venice, Italy.
  • Madeddu G; Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale Dell'Angelo, 30174 Venice, Italy.
  • Babudieri S; Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale Civile "S.S. Giovanni e Paolo", 30122 Venice, Italy.
Viruses ; 15(12)2023 12 12.
Article em En | MEDLINE | ID: mdl-38140655
ABSTRACT

BACKGROUND:

Women represent less than 5% of the incarcerated population in Italy, with very limited data on HCV infection. Higher HCV seroprevalence and active infection rates have been described among incarcerated females in available studies. Our aim is to compare the prevalence and cascade of care of HCV between male and female populations in Italian penitentiaries.

METHODS:

We conducted a multicentre, retrospective study comparing HCV seroprevalence, active infections, treatment, and SVR rates between female (Group A) and male (Group B) populations in Italian prison settings.

RESULTS:

No significant differences were found between the two groups regarding PWIDs (p = 0.16), nor in people living with HIV (p = 0.35) or HBV co-infection (p = 0.36). HCV seroprevalence was higher in Group A (p = 0.002). There was no statistically significant difference between the two groups regarding active infections (p = 0.41). Both groups showed a low level of fibrosis, and the dominant genotype was 3a. Almost all patients underwent antiviral treatment. All treated patients achieved SVR12.

CONCLUSIONS:

Our findings illuminate the importance of recognizing and addressing gender differences in HCV seroprevalence within penitentiary settings. Moving forward, addressing the unique needs of incarcerated females and optimizing HCV care for all incarcerated individuals are essential steps in the pursuit of achieving HCV micro-elimination goals.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prisioneiros / Infecções por HIV / Hepatite C Limite: Female / Humans / Male Idioma: En Revista: Viruses Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prisioneiros / Infecções por HIV / Hepatite C Limite: Female / Humans / Male Idioma: En Revista: Viruses Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália País de publicação: Suíça