Efficacy and safety of magnetic resonance-guided focused ultrasound for Parkinson's disease: a systematic review and meta-analysis.
Front Neurol
; 14: 1301240, 2023.
Article
em En
| MEDLINE
| ID: mdl-38146437
ABSTRACT
Objective:
Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is a novel noninvasive treatment for drug-resistant Parkinson's disease (PD) related tremor. This study aims to evaluate MRgFUS's efficacy and safety in PD through a systematic review and meta-analysis, examining pre-and post-treatment MDS-UPDRSIII and/or CRST scores and associated adverse events. Materials andmethods:
We conducted an extensive literature search across PubMed, Embase, Web of Science, and Cochrane Library databases, screening studies based on set criteria and analyzing MDS-UPDRSIII, CRST, and adverse events pre- and post-MRgFUS treatment.Results:
Out of 468 retrieved articles, 20 studies involving 258 patients, spanning 2014-2023, were included.17 studies indicated significant MDS-UPDRSIII score reductions post-MRgFUS treatment, while 3 showed significant CRST score declines. In the "on" medication state, pooled MDS-UPDRSIII scores at 1, 3, 6, and 12 months were 12.18 (95% CI 5.83-18.52), 12.10 (95% CI 8.22-15.97), 14.85 (95% CI 9.28-20.41), and 20.65 (95% CI 12.15-29.14) respectively. In the "off" state, scores were 11.45 (95% CI -3.50-26.40), 14.71 (95% CI 4.95-24.46), 21.52 (95% CI 19.28-23.75), and 22.28 (95% CI 15.26-29.30). Adverse events were typically mild and transient, with speech disturbances, ataxia, and sensory abnormalities being common post-operative neurological complications.Conclusion:
MRgFUS offers an effective and relatively safe treatment option for patients with drug-resistant PD-related tremor. Systematic review registration https//www.crd.york.ac.uk/prospero/, No. CRD42023428332.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Systematic_reviews
Idioma:
En
Revista:
Front Neurol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China