Demonstration of phosphorylcholine-specific IgE B cells in CBA/N mice.
J Immunol
; 123(3): 1039-43, 1979 Sep.
Article
em En
| MEDLINE
| ID: mdl-381515
ABSTRACT
CBA/N mice, which did not make anti-PC IgM or IgG antibody against PC-conjugated T-dependent or T-independent antigens, produced IgE antibody to PC-determinant when they were immunized with PC-KLH. PC-specificity of IgE antibody produced in CBA/N mice was determined by inhibition of PCA reaction with free PC-hapten or C-polysaccharide or by absorption of reaginic activity in the serum with C-polysaccharide. The presence of T15 idiotype on anti-PC IgE antibody produced in CBA/N x BALB/c F1 males also showed that anti-PC IgE antibody in defective mice was PC-specific. The results suggest that PC-specific B epsilon cells may belong to a subpopulation distinct from PC-specific precursors for IgM and IgG responses.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosforilcolina
/
Imunoglobulina E
/
Linfócitos B
/
Colina
/
Especificidade de Anticorpos
Limite:
Animals
Idioma:
En
Revista:
J Immunol
Ano de publicação:
1979
Tipo de documento:
Article