Self-Sorting Collagen Heterotrimers.
J Am Chem Soc
; 146(3): 1789-1793, 2024 01 24.
Article
em En
| MEDLINE
| ID: mdl-38156954
ABSTRACT
Nature uses elaborate methods to control protein assembly, including that of heterotrimeric collagen. Here, we established design principles for the composition and register-selective assembly of synthetic collagen heterotrimers. The assembly code enabled the self-sorting of eight different strands into threeâout of 512 possibleâtriple helices via complementary (4S)-aminoproline and aspartate residues. Native ESI-MS corroborated the specific assembly into coexisting heterotrimers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colágeno
/
Ácido Aspártico
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Suíça