Self-Sorting Collagen Heterotrimers.

Islami, Valdrin; Bittner, Philipp; Fiala, Tomas; Hentzen, Nina B; Zenobi, Renato; Wennemers, Helma

Islami, Valdrin; Bittner, Philipp; Fiala, Tomas; Hentzen, Nina B; Zenobi, Renato; Wennemers, Helma.

Afiliação

Islami V; Laboratory of Organic Chemistry, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
Bittner P; Laboratory of Organic Chemistry, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
Fiala T; Laboratory of Organic Chemistry, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
Hentzen NB; Laboratory of Organic Chemistry, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
Zenobi R; Laboratory of Organic Chemistry, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
Wennemers H; Laboratory of Organic Chemistry, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.

J Am Chem Soc ; 146(3): 1789-1793, 2024 01 24.

Article em En | MEDLINE | ID: mdl-38156954

ABSTRACT

ABSTRACT

Nature uses elaborate methods to control protein assembly, including that of heterotrimeric collagen. Here, we established design principles for the composition and register-selective assembly of synthetic collagen heterotrimers. The assembly code enabled the self-sorting of eight different strands into threeâout of 512 possibleâtriple helices via complementary (4S)-aminoproline and aspartate residues. Native ESI-MS corroborated the specific assembly into coexisting heterotrimers.

Assuntos

Ácido Aspártico; Colágeno; Multimerização Proteica; Colágeno/química; Movimento Celular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colágeno / Ácido Aspártico Idioma: En Revista: J Am Chem Soc Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suíça

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