Delivery of external proteins into the cytoplasm using protein capsules modified with IgG on the surface, created from the amphiphilic two helix-bundle protein OLE-ZIP.

Takahashi, Kousuke; Nishiyama, Taiki; Umezawa, Naoki; Inoue, Yasumichi; Akiba, Isamu; Dewa, Takehisa; Ikeda, Atsushi; Mizuno, Toshihisa

Takahashi, Kousuke; Nishiyama, Taiki; Umezawa, Naoki; Inoue, Yasumichi; Akiba, Isamu; Dewa, Takehisa; Ikeda, Atsushi; Mizuno, Toshihisa.

Afiliação

Takahashi K; Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan. mizuno.toshihisa@nitech.ac.jp.
Nishiyama T; Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan. mizuno.toshihisa@nitech.ac.jp.
Umezawa N; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.
Inoue Y; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.
Akiba I; Faculty of Environmental Engineering, the University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, Fukuoka 808-0135, Japan.
Dewa T; Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan. mizuno.toshihisa@nitech.ac.jp.
Ikeda A; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, Aichi 466-8555, Japan.
Mizuno T; Applied Chemistry Program, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527, Japan.

Chem Commun (Camb) ; 60(8): 968-971, 2024 Jan 23.

Article em En | MEDLINE | ID: mdl-38165681

ABSTRACT

ABSTRACT

This study explores a new method for delivering therapeutic proteins into specific cells using OLE-ZIP capsules that present IgG. OLE-ZIP capsules is a spherical caspules prepared from amphihilic dimetic coiled-coil peptide, OLE-ZIP. Upon presenting cetuximab, these capsules showed preferential uptake in A431 cells and increased cytotoxicity when loaded with RNase A.

Assuntos

Imunoglobulina G; Peptídeos; Citoplasma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Imunoglobulina G Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido

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