Cut-off value for interleukin-34 as an additional potential inflammatory biomarker for estimation of slow coronary flow risk.
BMC Cardiovasc Disord
; 24(1): 2, 2024 01 02.
Article
em En
| MEDLINE
| ID: mdl-38166811
ABSTRACT
BACKGROUND:
Inflammatory markers may provide insights into the underlying mechanisms of slow coronary flow (SCF), including subclinical atherosclerosis and endothelial dysfunction. Interleukin-34 (IL-34), known for its role in immuno-inflammatory diseases, might hold significance in SCF. We aimed to explore the potential association between IL-34 and SCF in patients undergoing diagnostic elective coronary angiography.METHODS:
This observational, cross-sectional study enrolled 256participants:
124 with SCF and 132 with normal coronary flow (NCF). All participants had undergone outpatient coronary angiography for suspected coronary artery disease. SCF assessment employed the TIMI frame count (TFC) for quantifying coronary flow rate.RESULTS:
SCF patients exhibited significantly elevated TFC in all three major coronary arteries compared to controls (p < 0.05). IL-34 displayed a noteworthy positive correlation with average TFC [for allparticipants:
r = 0.514, p < 0.001; for SCF patients r = 0.526, p < 0.001; for normal controls r = -0.288, p > 0.05]. Similarly, high-sensitivity C-reactive protein (hsCRP) showed a significant and positive relationship with average TFC [for allparticipants:
r = 0.504, p < 0.001; for SCF patients r = 0.558, p < 0.001; for normal controls r = -0.148, p > 0.05]. SCF patients presented coronary arteries of larger size compared to controls.CONCLUSION:
Mean coronary diameter and IL-34 emerged as independent predictors of SCF. Additionally, hsCRP, mean coronary diameter, and IL-34 exhibited a positive correlation with mean TFC values. IL-34 appears to be a more effective indicator than hsCRP in SCF patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Circulação Coronária
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
BMC Cardiovasc Disord
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Turquia
País de publicação:
Reino Unido