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Hydroxyurea reduces infections in children with sickle cell anemia in Uganda.
Namazzi, Ruth; Bond, Caitlin; Conroy, Andrea L; Datta, Dibyadyuti; Tagoola, Abner; Goings, Michael J; Jang, Jeong Hoon; Ware, Russell E; Opoka, Robert; John, Chandy C.
Afiliação
  • Namazzi R; Department of Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
  • Bond C; Global Health Uganda, Kampala, Uganda.
  • Conroy AL; Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN.
  • Datta D; Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN.
  • Tagoola A; Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN.
  • Goings MJ; Department of Pediatrics, Jinja Regional Referral Hospital, Jinja, Uganda.
  • Jang JH; Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, IN.
  • Ware RE; Underwood International College and Department of Applied Statistics, Yonsei University, Seoul, Korea.
  • Opoka R; Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
  • John CC; Global Health Uganda, Kampala, Uganda.
Blood ; 143(14): 1425-1428, 2024 Apr 04.
Article em En | MEDLINE | ID: mdl-38169476
ABSTRACT
ABSTRACT After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anemia Falciforme / Malária Limite: Child / Humans País/Região como assunto: Africa Idioma: En Revista: Blood Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Uganda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anemia Falciforme / Malária Limite: Child / Humans País/Região como assunto: Africa Idioma: En Revista: Blood Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Uganda