Evaluation of cell proliferation marker CDC-7 in salivary adenoid cystic carcinoma.

ABSTRACT

BACKGROUND: Adenoid cystic carcinoma (AdCC) is considered one of the most common destructive types of malignant salivary gland tumor that have high affinity to perineural invasion (PNI). This study was conducted to access different histological features of AdCC, and assessment of the immunohistochemical expression of CDC-7. METHODS: Thirty formalin-fixed paraffin incorporated tissue blocks of AdCC were classified according to the WHO histopathological types. The immune-expression of CDC-7 positive area was evaluated according to percentage area as following Negative = 0 %, Weak = 1-10 %, Moderate = 11-49 %, and Strong = 50-100. The correlations between expression of the marker and different clinico-pathological variables were investigated using Chi-square (χ2) test. The P-value ≤ 0.05 was considered statistically significant. RESULTS: The expression of CDC-7 revealed statistical significant difference between the different tumor types (p ≤ 0.05). CONCLUSION: The biological behavior of AdCC can be predicated from the expression of CDC-7.