Preparation and evaluation of 3,4''-ester derivatives of 16-membered macrolide antibiotics related to tylosin.
J Antibiot (Tokyo)
; 39(12): 1724-35, 1986 Dec.
Article
em En
| MEDLINE
| ID: mdl-3818446
ABSTRACT
A large group of ester derivatives of tylosin-related macrolides was prepared in which the hydroxyl groups at C-3 and C-4'' were acylated by either chemical or biochemical methods. Most of the derivatives exhibited excellent in vitro antimicrobial activity. However, only the 3,4''-diacyl derivatives of tylosin and macrocin showed any significant improvements of in vivo efficacy against experimental infections in rodents.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Leucomicinas
/
Antibacterianos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1986
Tipo de documento:
Article