Quantifying orthogonal barcodes for sequence census assays.
Bioinform Adv
; 4(1): vbad181, 2024.
Article
em En
| MEDLINE
| ID: mdl-38213823
ABSTRACT
Summary:
Barcode-based sequence census assays utilize custom or random oligonucloetide sequences to label various biological features, such as cell-surface proteins or CRISPR perturbations. These assays all rely on barcode quantification, a task that is complicated by barcode design and technical noise. We introduce a modular approach to quantifying barcodes that achieves speed and memory improvements over existing tools. We also introduce a set of quality control metrics, and accompanying tool, for validating barcode designs. Availability and implementation https//github.com/pachterlab/kb_python, https//github.com/pachterlab/qcbc.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Bioinform Adv
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos