A Radiomic "Warning Sign" of Progression on Brain MRI in Individuals with MS.
AJNR Am J Neuroradiol
; 45(2): 236-243, 2024 02 07.
Article
em En
| MEDLINE
| ID: mdl-38216299
ABSTRACT
BACKGROUND AND PURPOSE:
MS is a chronic progressive, idiopathic, demyelinating disorder whose diagnosis is contingent on the interpretation of MR imaging. New MR imaging lesions are an early biomarker of disease progression. We aimed to evaluate a machine learning model based on radiomics features in predicting progression on MR imaging of the brain in individuals with MS. MATERIALS ANDMETHODS:
This retrospective cohort study with external validation on open-access data obtained full ethics approval. Longitudinal MR imaging data for patients with MS were collected and processed for machine learning. Radiomics features were extracted at the future location of a new lesion in the patients' prior MR imaging ("prelesion"). Additionally, "control" samples were obtained from the normal-appearing white matter for each participant. Machine learning models for binary classification were trained and tested and then evaluated the external data of the model.RESULTS:
The total number of participants was 167. Of the 147 in the training/test set, 102 were women and 45 were men. The average age was 42 (range, 21-74 years). The best-performing radiomics-based model was XGBoost, with accuracy, precision, recall, and F1-score of 0.91, 0.91, 0.91, and 0.91 on the test set, and 0.74, 0.74, 0.74, and 0.70 on the external validation set. The 5 most important radiomics features to the XGBoost model were associated with the overall heterogeneity and low gray-level emphasis of the segmented regions. Probability maps were produced to illustrate potential future clinical applications.CONCLUSIONS:
Our machine learning model based on radiomics features successfully differentiated prelesions from normal-appearing white matter. This outcome suggests that radiomics features from normal-appearing white matter could serve as an imaging biomarker for progression of MS on MR imaging.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Radiômica
Tipo de estudo:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Aspecto:
Ethics
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Irlanda
País de publicação:
Estados Unidos