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Ginsenoside Rb2 exhibits therapeutic value for male osteoporosis in orchiectomy mice by suppressing osteoclastogenesis and modulating NF-κB/MAPK signaling pathways.
Ma, Yanhuai; Li, Jianliang; Mai, Jiale; Guo, Huizhi; Ding, Lingli; Li, Jinglan; Xiao, Jiacong; Li, Miao; Fang, Weihua; Zhang, Shuncong; Xu, Liangliang; Wang, Haibin.
Afiliação
  • Ma Y; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China. hipknee@163.com.
  • Li J; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Mai J; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China. hipknee@163.com.
  • Guo H; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Ding L; Guangzhou First People's Hospital, Second Affiliated Hospital of South China University of Technology, Guangzhou, China.
  • Li J; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Xiao J; Foshan Hospital of Chinese Medicine, Eighth Clinical School, Guangzhou University of Chinese Medicine, Foshan, China.
  • Li M; Department of Spine Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Fang W; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China. hipknee@163.com.
  • Zhang S; The Laboratory of Orthopaedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Xu L; Department of Spine Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Wang H; First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China. hipknee@163.com.
Food Funct ; 15(3): 1583-1597, 2024 Feb 05.
Article em En | MEDLINE | ID: mdl-38240189
ABSTRACT
Osteoporosis (OP) is a systemic disorder characterized by decreased bone mass as well as deteriorated microarchitecture. Although OP in men is common, it has received much less attention than that in women. Ginseng, a famous traditional herb in Asia, is used to strengthen and repair bones by invigorating vital bioenergy and maintaining body homeostasis in dietary intake and clinical applications. However, there is currently no study investigating the impact of ginseng and its active compounds on male osteoporosis. In this study, RNA sequencing and bioinformatic analysis were conducted to reveal the influence of Ginsenoside-Rb2 on RAW264.7 cells and its underlying signaling pathways. The potential anti-osteoporosis effects of Rb2 as well as its molecular mechanisms were elucidated in RAW264.7 cells and BMMs by TRAP staining, F-actin belt staining, qRT-PCR and WB. Moreover, orchiectomy (ORX) was utilized to demonstrate the influence of Rb2 on bone mass loss in vivo by micro-CT scanning, and H&E, TRAP, and IHC staining. The results suggested that Rb2 suppressed osteoclastogenesis and mitigated bone loss in orchiectomy mice through NF-κB/MAPK signaling pathways. These findings indicate that ginseng as well as its active component Rb2 have potential therapeutic value in the management of osteoporosis in men.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Ginsenosídeos Limite: Animals / Female / Humans / Male Idioma: En Revista: Food Funct Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Ginsenosídeos Limite: Animals / Female / Humans / Male Idioma: En Revista: Food Funct Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China