Application of fractional carbon dioxide laser monotherapy in keloids: A meta-analysis.
J Cosmet Dermatol
; 23(4): 1178-1186, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38251806
ABSTRACT
BACKGROUND:
There is no evidence-based guidance on the use of fractional CO2 laser in the excision of scars.AIM:
To explore the effectiveness and safety of fractional CO2 laser in the treatment of keloids.METHODS:
In this meta-analysis, we searched the PubMed, Embase, and Cochrane databases from inception to April 2023. We only included studies reporting fractional CO2 laser treatment of keloids. We excluded duplicate published studies, incomplete studies, those with incomplete data, animal experiments, literature reviews, and systematic studies.RESULTS:
The pooled results showed that the Vancouver Scar Scale (VSS) parameters of height weighted mean difference (WMD) = -1.10, 95% confidence interval (CI) -1.46 to -0.74), pigmentation (WMD = -0.61, 95% CI -1.00 to -0.21), and pliability (WMD = -0.90, 95% CI -1.17 to -0.63) were significantly improved after fractional CO2 laser treatment of keloids. However, vascularity did not significantly change. Additionally, the total VSS was significantly improved after treatment (WMD = -4.01, 95% CI -6.22 to -1.79). The Patient Scars Assessment Scale was significantly improved after treatment (WMD = -15.31, 95% CI -18.31 to -12.31). Regarding safety, the incidences of hyperpigmentation, hypopigmentation, pain, telangiectasia, and atrophy were 5%, 0%, 11%, 2% (95% CI 0%-6%), and 0% (95% CI 0%-4%), respectively.CONCLUSIONS:
Fractional CO2 laser is effective in the treatment of keloids and can effectively improve the height, pigmentation, and pliability of scars, and patients are satisfied with this treatment. Further studies should explore the role of combination therapy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cicatriz Hipertrófica
/
Lasers de Gás
/
Queloide
Tipo de estudo:
Guideline
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
J Cosmet Dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
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UNITED KINGDOM