Trans-stimulation and driving forces for GSH transport in sinusoidal membrane vesicles from rat liver.
Biochem Biophys Res Commun
; 143(1): 377-82, 1987 Feb 27.
Article
em En
| MEDLINE
| ID: mdl-3827928
ABSTRACT
Sinusoidal membrane vesicles from rat liver were employed to study the characteristics of GSH transport. Saturable concentration dependent uptake was best described by the sum of a high and low Km transport. Preloading with GSH markedly stimulated the initial uptake of GSH. GSH transport was electrogenic; uptake was enhanced by an inwardly directed K+ gradient which could be blocked by the K+-channel blocker, Ba2+. The other cations such as Na+, Li+ were poor substitutes for K+. These results therefore show that net GSH transport involves movement of K+.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glutationa
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1987
Tipo de documento:
Article