Bioengineering vascularized liver tissue for biomedical research and application.
Scand J Gastroenterol
; 59(5): 623-629, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38319110
ABSTRACT
The liver performs a wide range of biological functions that are essential to body homeostasis. Damage to liver tissue can result in reduced organ function, and if chronic in nature can lead to organ scarring and progressive disease. Currently, donor liver transplantation is the only longterm treatment for end-stage liver disease. However, orthotopic organ transplantation suffers from several drawbacks that include organ scarcity and lifelong immunosuppression. Therefore, new therapeutic strategies are required. One promising strategy is the engineering of implantable and vascularized liver tissue. This resource could also be used to build the next generation of liver tissue models to better understand human health, disease and aging in vitro. This article reviews recent progress in the field of liver tissue bioengineering, including microfluidic-based systems, bio-printed vascularized tissue, liver spheroids and organoid models, and the induction of angiogenesis in vivo.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Engenharia Tecidual
/
Fígado
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Scand J Gastroenterol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Irã