Female reproductive histories and the risk of chronic obstructive pulmonary disease.
Thorax
; 79(6): 508-514, 2024 May 20.
Article
em En
| MEDLINE
| ID: mdl-38350732
ABSTRACT
BACKGROUND:
Female reproductive factors may influence the development of chronic obstructive pulmonary disease (COPD) through the female hormonal environment, but studies on this topic are limited. This study aimed to assess whether age at menarche, number of children, infertility, miscarriage, stillbirth and age at natural menopause were associated with the risk of COPD.METHODS:
Women from three cohorts with data on reproductive factors, COPD and covariates were included. Cause specific Cox regression models were adjusted for birth year, race, educational level, body mass index and pack years of smoking, stratified by asthma, and incorporating interaction between birth year and time. Between cohort differences and within cohort correlations were taken into account.RESULTS:
Overall, 2 83 070 women were included and 10 737 (3.8%) developed COPD after a median follow-up of 11 (IQR 10-12) years. Analyses revealed a U shaped association between age at menarche and COPD (≤11 vs 13 HR 1.17, 95% CI 1.11 to 1.23; ≥16 vs 13 HR 1.24, 95% CI 1.21 to 1.27). Women with three or more children (3 vs 2 HR 1.14, 95% CI 1.12 to 1.17; ≥4 vs 2 HR 1.34, 95% CI 1.28 to 1.40), multiple miscarriages (2 vs 0 HR 1.28, 95% CI 1.24 to 1.32; ≥3 vs 0 HR 1.36, 95% CI 1.30 to 1.43) or stillbirth (1 vs 0 HR 1.38, 95% CI 1.25 to 1.53; ≥2 vs 0 HR 1.67, 95% CI 1.32 to 2.10) were at a higher risk of COPD. Among postmenopausal women, earlier age at natural menopause was associated with an increased risk of COPD (<40 vs 50-51 HR 1.69, 95% CI 1.63 to 1.75; 40-44 vs 50-51 HR 1.42, 95% CI 1.38 to 1.47).CONCLUSIONS:
Multiple female reproductive factors, including age at menarche, number of children, miscarriage, stillbirth, and age at natural menopause were associated with the risk of COPD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Menarca
/
Menopausa
/
Aborto Espontâneo
/
História Reprodutiva
/
Doença Pulmonar Obstrutiva Crônica
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
/
Pregnancy
Idioma:
En
Revista:
Thorax
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Austrália
País de publicação:
Reino Unido