Histological evidence of hypothyroidism in mice chronically exposed to conventional farming.
Environ Toxicol Pharmacol
; 106: 104387, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38364936
ABSTRACT
Worldwide, disorders of the thyroid gland are a growing concern; such can be caused by exposure to contaminants, including agrochemicals used in conventional agriculture, which act as endocrine disruptors. The purpose of this study is to evaluate whether or not exposure to an environment with conventional agriculture leads to thyroid disruption. Mus musculus were used as bioindicator species, captured in two sites a farm where conventional agriculture is practiced, and a place without agriculture. Thyroid histomorphometric and morphologic data were analyzed. The impacts of the agricultural environment over the thyroid were revealed, as indications of hypothyroidism were observed in exposed mice the area and volume of epithelial cells were much lower. Alterations in thyroid histomorphology were also observed lower follicular sphericity, irregularly delimited epithelium and increased exfoliation into the colloid. These results highlight the need for transition from current conventional agricultural systems towards organic systems.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disruptores Endócrinos
/
Hipotireoidismo
Limite:
Animals
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Ano de publicação:
2024
Tipo de documento:
Article