Histological predictors of outcome for cutaneous squamous cell carcinoma in renal transplant patients: A case-control study.
JAAD Int
; 15: 51-58, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38371661
ABSTRACT
Background:
Cutaneous squamous cell carcinoma is a significant cause of morbidity for immunosuppressed patients such as organ transplant recipients; however, histological parameters which predict the likelihood of tumor progression are typically based on general population studies in which immunosuppressed patients represent only a small fraction of cases.Objectives:
To determine the histological parameters which have independent prognostic value for cutaneous squamous cell carcinoma arising in renal transplant recipients.Methods:
Case-control study incorporating a retrospective blinded histological review of 70 archived specimens of cutaneous squamous cell carcinoma diagnosed in renal transplant recipients, comprising 10 cases where the tumor had progressed and 60 controls.Results:
Progression was significantly associated with head and neck location, size, depth, poor histological grade, perineural invasion (including small caliber perineural invasion), lymphovascular invasion, and a desmoplastic growth pattern.Limitations:
The retrospective nature and the low number of cases compared to controls.Conclusion:
In immunosuppressed patients both small caliber perineural invasion and a desmoplastic growth pattern may also have prognostic significance in addition to other histological parameters already recognized in formal staging schemes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
JAAD Int
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Austrália