Structure of the GDP-bound state of the SRP GTPase FlhF.
Acta Crystallogr F Struct Biol Commun
; 80(Pt 3): 53-58, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38376823
ABSTRACT
The GTPase FlhF, a signal recognition particle (SRP)-type enzyme, is pivotal for spatial-numerical control and bacterial flagella assembly across diverse species, including pathogens. This study presents the X-ray structure of FlhF in its GDP-bound state at a resolution of 2.28â
Å. The structure exhibits the classical N- and G-domain fold, consistent with related SRP GTPases such as Ffh and FtsY. Comparative analysis with GTP-loaded FlhF elucidates the conformational changes associated with GTP hydrolysis. These topological reconfigurations are similarly evident in Ffh and FtsY, and play a pivotal role in regulating the functions of these hydrolases.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Partícula de Reconhecimento de Sinal
/
GTP Fosfo-Hidrolases
Idioma:
En
Revista:
Acta Crystallogr F Struct Biol Commun
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha