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SARS-CoV-2 infection during pregnancy and the risk of adverse maternal outcomes in the Republic of Georgia: a national birth registry-based cohort study.
Skhvitaridze, Natia; Gamkrelidze, Amiran; Manjavidze, Tinatin; Brenn, Tormod; Rylander, Charlotta.
Afiliação
  • Skhvitaridze N; Department of Community Medicine, UiT The Arctic University of Norway, N-9037, Langnes, Tromsø, PO Box 6050, Norway. natia.skhvitaridze@uit.no.
  • Gamkrelidze A; National Center for Disease Control and Public Health, 99 Kakheti highway, Tbilisi, Georgia. natia.skhvitaridze@uit.no.
  • Manjavidze T; The University of Georgia, 77a Kostava Street, Tbilisi, Georgia. natia.skhvitaridze@uit.no.
  • Brenn T; The University of Georgia, 77a Kostava Street, Tbilisi, Georgia.
  • Rylander C; Department of Community Medicine, UiT The Arctic University of Norway, N-9037, Langnes, Tromsø, PO Box 6050, Norway.
BMC Pregnancy Childbirth ; 24(1): 156, 2024 Feb 22.
Article em En | MEDLINE | ID: mdl-38388360
ABSTRACT

BACKGROUND:

Georgia experienced an increase in maternal deaths (MD) during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which warrants further investigation. This study aimed to assess associations between timing of SARS-CoV-2 infection during pregnancy and MD, post-delivery intensive care unit (ICU) admission, and caesarean section (CS) delivery.

METHODS:

We performed a national birth registry-based cohort study of pregnant women who had completed 22 weeks of gestation and delivered between February 28, 2020, and August 31, 2022. The data were linked to coronavirus disease 2019 (COVID-19) testing, vital, and immunization registries. Pregnant women were classified into three groups confirmed SARS-CoV-2 infection from conception through 31 days before delivery; confirmed infection within 30 days before or at delivery; and women negative for SARS-CoV-2 infection or without any test results (reference group). Multivariable logistic regression was used to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CIs).

RESULTS:

Among 111,493 pregnant women, 16,751 had confirmed infection during pregnancy, and 7,332 were fully vaccinated against COVID-19 before delivery. Compared to the reference group, those with confirmed infection within 30 days before or at delivery experienced increased odds of MD (aOR 43.11, 95% CI, 21.99-84.55), post-delivery ICU admission (aOR 5.20, 95% CI, 4.05-6.67), and CS delivery (aOR 1.11, 95% CI, 1.03-1.20).

CONCLUSIONS:

Pregnant women in Georgia with confirmed SARS-CoV-2 infection within 30 days before or at delivery experienced a considerably higher risk of MD and post-delivery ICU admission and a slightly higher risk for CS delivery. Additionally, the results highlighted that most pregnant women were not vaccinated against COVID-19. These findings should alert stakeholders that adherence to public health preventive measures needs to be improved.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Nascimento Prematuro / Morte Materna / COVID-19 Limite: Female / Humans / Pregnancy País/Região como assunto: America do norte / Europa Idioma: En Revista: BMC Pregnancy Childbirth Assunto da revista: OBSTETRICIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Noruega País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Nascimento Prematuro / Morte Materna / COVID-19 Limite: Female / Humans / Pregnancy País/Região como assunto: America do norte / Europa Idioma: En Revista: BMC Pregnancy Childbirth Assunto da revista: OBSTETRICIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Noruega País de publicação: Reino Unido