Crossprotection induced by virus-like particles containing influenza dual-hemagglutinin and M2 ectodomain.
Nanomedicine (Lond)
; 19(9): 741-754, 2024 04.
Article
em En
| MEDLINE
| ID: mdl-38390688
ABSTRACT
Aims:
To develop an effective universal vaccine against antigenically different influenza viruses. Materials &methods:
We generated influenza virus-like particles (VLPs) expressing the H1 and H3 antigens with or without M2e5x. VLP-induced immune responses and crossprotection against H1N1, H3N2 or H5N1 viruses were assessed to evaluate their protective efficacy.Results:
H1H3M2e5x immunization elicited higher crossreactive IgG antibodies than H1H3 VLPs. Upon challenge, both VLPs enhanced lung IgG, IgA and germinal center B-cell responses compared with control. While these VLPs conferred protection, H1H3M2e5x showed greater lung viral load reduction than H1H3 VLPs with minimal body weight loss.Conclusion:
Utilizing VLPs containing dual-hemagglutinin, along with M2e5x, can be a vaccination strategy for inducing crossprotection against influenza A viruses.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Infecções por Orthomyxoviridae
/
Influenza Humana
/
Vírus da Influenza A Subtipo H1N1
/
Virus da Influenza A Subtipo H5N1
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nanomedicine (Lond)
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM