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Instability of Healthy Overweight and Obesity Phenotypes over the Long Term in Young Participants in the HARVEST Study: Influence of Sex.
Palatini, Paolo; Saladini, Francesca; Mos, Lucio; Vriz, Olga; Ermolao, Andrea; Battista, Francesca; Mazzer, Adriano; Canevari, Mattia; Rattazzi, Marcello.
Afiliação
  • Palatini P; Studium Patavinum and Department of Medicine, University of Padova, 35128 Padova, Italy.
  • Saladini F; Cittadella Town Hospital, 35013 Cittadella, Italy.
  • Mos L; San Antonio Hospital, 33038 San Daniele del Friuli, Italy.
  • Vriz O; San Antonio Hospital, 33038 San Daniele del Friuli, Italy.
  • Ermolao A; Studium Patavinum and Department of Medicine, University of Padova, 35128 Padova, Italy.
  • Battista F; Studium Patavinum and Department of Medicine, University of Padova, 35128 Padova, Italy.
  • Mazzer A; Vittorio Veneto Town Hospital, 31029 Vittorio Veneto, Italy.
  • Canevari M; San Antonio Hospital, 33038 San Daniele del Friuli, Italy.
  • Rattazzi M; Studium Patavinum and Department of Medicine, University of Padova, 35128 Padova, Italy.
J Cardiovasc Dev Dis ; 11(2)2024 Jan 31.
Article em En | MEDLINE | ID: mdl-38392261
ABSTRACT

BACKGROUND:

Whether healthy metabolic status is stable or only temporary is still controversial. The aim of the present study was to determine the frequency of the transition from metabolically healthy to metabolically unhealthy status, or vice versa, over the long term.

METHODS:

We examined 970 individuals of 18 to 45 years of age. The participants' mean age was 33.1 ± 8.6 years and mean BP was 145.5 ± 10.6/93.5 ± 5.7 mmHg. Participants were classified into four groups according to whether they had normal weight or overweight/obesity (OwOb) and were metabolically healthy or unhealthy. After 7.5 years, 24.3% of men and 41.9% of women in the metabolically healthy normal-weight group remained metabolically healthy (p < 0.0001). Among the metabolically healthy OwOb participants, 31.9% remained metabolically healthy, with a similar frequency in men and women. However, more OwOb women (19.1%) than men (5.7%) achieved normal weight (p < 0.0001). Among the metabolically unhealthy OwOb subjects, 81.8% of men and 69.3% of women remained metabolically unhealthy, 7.4% of men and 12.0% of women transitioned to OwOb healthy status, and 10.7% of men and 18.7% of women achieved normal weight (men versus women, p < 0.0001). Predictors of transition to unhealthy status were high BP, high BMI, and smoking. Male sex was a borderline predictor of progression to unhealthy status in OwOb participants (p = 0.073).

CONCLUSION:

These data show that metabolically healthy status is a highly unstable condition in both normal-weight and OwOb individuals. The impairment of metabolic status was more frequent in men than in women. Lifestyle counseling produced beneficial effects in almost one-third of metabolically unhealthy OwOb women and in less than one-fifth of men.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cardiovasc Dev Dis Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cardiovasc Dev Dis Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália País de publicação: Suíça