Differentiation of Hamartomas and Malignant Lung Tumors in Single-Phased Dual-Energy Computed Tomography.
Tomography
; 10(2): 255-265, 2024 Feb 11.
Article
em En
| MEDLINE
| ID: mdl-38393288
ABSTRACT
This study investigated the efficacy of single-phase dual-energy CT (DECT) in differentiating pulmonary hamartomas from malignant lung lesions using virtual non-contrast (VNC), iodine, and fat quantification. Forty-six patients with 47 pulmonary lesions (mean age 65.2 ± 12.1 years; hamartomas-to-malignant lesions = 2225; male 67%) underwent portal venous DECT using histology, PET-CT and follow-up CTs as a reference. Quantitative parameters such as VNC, fat fraction, iodine density and CT mixed values were statistically analyzed. Significant differences were found in fat fractions (hamartomas 48.9%; malignancies 22.9%; p ≤ 0.0001) and VNC HU values (hamartomas -20.5 HU; malignancies 17.8 HU; p ≤ 0.0001), with hamartomas having higher fat content and lower VNC HU values than malignancies. CT mixed values also differed significantly (p ≤ 0.0001), but iodine density showed no significant differences. ROC analysis favored the fat fraction (AUC = 96.4%; sensitivity 100%) over the VNC, CT mixed value and iodine density for differentiation. The study concludes that the DECT-based fat fraction is superior to the single-energy CT in differentiating between incidental pulmonary hamartomas and malignant lesions, while post-contrast iodine density is ineffective for differentiation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hamartoma
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Iodo
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Neoplasias Pulmonares
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Tomography
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha