Associations of glycosylated hemoglobin, pre-diabetes, and type 2 diabetes with incident lung cancer: A large prospective cohort study.
Diabetes Metab Syndr
; 18(2): 102968, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38402819
ABSTRACT
BACKGROUND:
The association of pre-diabetes and type 2 diabetes (T2D) with incident lung cancer is uncertain, and the incident risk across the glycemic spectrum is unclear. We aimed to explore the associations of glycosylated hemoglobin (HbA1c), pre-diabetes, and T2D with incident lung cancer in a large prospective cohort.METHODS:
Leveraging a total of 210,779 cancer-free adults recruited in the UK Biobank between 2006 and 2010. We performed multivariable Cox proportional hazards models and restricted cubic spline methods to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the associations of HbA1c, pre-diabetes, and T2D with incident lung cancer.RESULTS:
During a median follow-up of 11.06 years, 1738 incident lung cancer cases were ascertained. The incidence of lung cancer was 20% higher among people with diabetes (HR 1.20, 95% CI 1.02 to 1.42) and 38% higher among people with pre-diabetes (HR 1.38, 95% CI 1.15 to 1.65). After dividing people with diabetes by whether taking antidiabetic medications, the incidence was 28% higher among people with diabetes without medications (HR 1.28, 95% CI 1.02 to 1.61) and 15% higher among people with diabetes with medications (HR 1.15, 95% CI 0.93 to 1.41). The increased risk of incident lung cancer for each standard deviation (6.45 mmol/mol) increase in HbA1c was more pronounced across HbA1c values of 32-42 mmol/mol (HR 1.37, 95% CI 1.18 to 1.59). The risk was more pronounced among participants <60 years.CONCLUSIONS:
Pre-diabetes and T2D are associated with an increased incidence of lung cancer. The increased risk of incident lung cancer is more pronounced across HbA1c values of 32-42 mmol/mol, which are currently considered normal values.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estado Pré-Diabético
/
Diabetes Mellitus Tipo 2
/
Neoplasias Pulmonares
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Diabetes Metab Syndr
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China