Immune-mediated polyarthritis and anterior uveitis secondary to zonisamide administration in a dog with refractory epilepsy.
Vet Med Sci
; 10(2): e1374, 2024 03.
Article
em En
| MEDLINE
| ID: mdl-38403976
ABSTRACT
The objective of this article is to describe a case of suspected zonisamide-induced immune-mediated polyarthritis (IMPA) and anterior uveitis in a dog. A 7-year-old male neutered Siberian Husky with a history of refractory idiopathic epilepsy was presented for cluster seizures. Following the addition of zonisamide to the antiepileptic regime, the dog developed new IMPA and anterior uveitis. Within a few weeks of discontinuation of the zonisamide, the dog's IMPA and anterior uveitis resolved. These immune-mediated conditions were thus presumed to be an idiosyncratic reaction to zonisamide. To our knowledge, this is the first report of IMPA and anterior uveitis in dogs associated with zonisamide administration at its recommended dose.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
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Artrite
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Uveíte Anterior
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Doenças do Cão
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Epilepsia Resistente a Medicamentos
Limite:
Animals
Idioma:
En
Revista:
Vet Med Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos