Low thyroid function is associated with metabolic dysfunction-associated steatotic liver disease.
JGH Open
; 8(2): e13038, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38405186
ABSTRACT
Background and Aim:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is recently introduced to better highlight the pathogenic significance of cardiometabolic dysfunction, as compared with non-alcoholic fatty liver disease. This study aimed to investigate the association between low thyroid function and MASLD in the new context.Methods:
We recruited 2901 participants for our retrospective cohort study from 2016 to 2021. Participants were divided into strict-normal thyroid function and low thyroid function groups (low-normal thyroid function, subclinical hypothyroidism) based on initial thyroid stimulating hormone (TSH) levels, respectively. Cox regression models were used to estimate the hazard ratios (HRs) and 95% CI.Results:
During a median follow-up of 15.6 months, 165 (8.9%) strict-normal thyroid function subjects and 141 (13.4%) low thyroid function subjects developed MASLD; this result was statistically relevant (P < 0.05). Univariate regression analysis showed that low thyroid function and subclinical hypothyroidism were statistically significantly associated with MASLD (low thyroid function HR1.53; 95% CI 1.22-1.92; subclinical hypothyroidism HR1.95; 95% CI 1.47-2.60).Conclusions:
MASLD is associated with low thyroid function and the relationship between MASLD and low thyroid function is independent.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
JGH Open
Ano de publicação:
2024
Tipo de documento:
Article