[Recognition and management of relevant comorbidities in chronic spontaneous urticaria]. / Erkennen und Management relevanter Komorbiditäten bei chronischer spontaner Urtikaria.
Dermatologie (Heidelb)
; 75(4): 289-294, 2024 Apr.
Article
em De
| MEDLINE
| ID: mdl-38411698
ABSTRACT
Various mechanisms contributing to the activity of chronic spontaneous urticaria (CU) have been postulated. Associated comorbidities are increasingly leading to the discovery of further signaling pathways which may support the activity of chronic urticaria or contribute to low-grade systemic inflammation. Moreover psychoimmunological factors may also be involved. The aim of this work is to improve the clinical care of patients with CU by increasing knowledge regarding optional influencing factors due to comorbidities and to possibly influence disease activity. Chronic urticaria due to autoimmune mechanisms may dispose to other autoimmune diseases, especially autoimmune thyroiditis, which can trigger chronic disease. Association of CU with metabolic syndrome has received little attention to date. Obesity may contribute to low-grade systemic inflammation by cytokine-secreting adipose tissue and hence to mediator-release of mast cells. Furthermore, neuroimmunological pathways, especially increased release of substance P, an activating ligand of Mas-related G protein-coupled receptor X2 (MRGPX2) on mast cells, should be addressed when optimizing therapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Urticária
/
Urticária Crônica
Limite:
Humans
Idioma:
De
Revista:
Dermatologie (Heidelb)
Ano de publicação:
2024
Tipo de documento:
Article