Revolutionizing biomedical research: The imperative need for heart-kidney-connected organoids.
APL Bioeng
; 8(1): 010902, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38420624
ABSTRACT
Organoids significantly advanced our comprehension of organ development, function, and disease modeling. This Perspective underscores the potential of heart-kidney-connected organoids in understanding the intricate relationship between these vital organs, notably the cardiorenal syndrome, where dysfunction in one organ can negatively impact the other. Conventional models fall short in replicating this complexity, necessitating an integrated approach. By co-culturing heart and kidney organoids, combined with microfluidic and 3D bioprinting technologies, a more accurate representation of in vivo conditions can be achieved. Such interconnected systems could revolutionize our grasp of multi-organ diseases, drive drug discovery by evaluating therapeutic agents on both organs simultaneously, and reduce the need for animal models. In essence, heart-kidney-connected organoids present a promising avenue to delve deeper into the pathophysiology underlying cardiorenal disorders, bridging existing knowledge gaps, and advancing biomedical research.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
APL Bioeng
Ano de publicação:
2024
Tipo de documento:
Article