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Epilepsia Partialis Continua as a Sequelae of Measles Infection in Children With Hematolymphoid Malignancies.
Sharma, Sudivya; Dhamne, Chetan; Bhosale, Shilpushp; Parambil, Badira; Divatia, Jigeeshu; Chinnaswamy, Girish; Patil, Vasundhara; Joshi, Rishikesh; Epari, Sridhar; Mahadevan, Anita; Vaidya, Sunil; Kulkarni, Shilpa; Kulkarni, Atul; Patil, Vijaya; Srinivasan, Shyam; Gollamudi, Venkata Rama Mohan; Roy Moulik, Nirmalya; Prasad, Maya; Narula, Gaurav; Banavali, Shripad.
Afiliação
  • Sharma S; Division of Critical Care Medicine, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Dhamne C; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Bhosale S; Division of Critical Care Medicine, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Parambil B; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Divatia J; Division of Critical Care Medicine, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Chinnaswamy G; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Patil V; Department of Radiology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Joshi R; Department of Neurology, KEM Hospital, Mumbai, India.
  • Epari S; Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Mahadevan A; Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India.
  • Vaidya S; Virus Registry and Virus Repository, National Institute of Virology, Pune, India.
  • Kulkarni S; Department of Neurology, Wadia Children's Hospital, Mumbai, India.
  • Kulkarni A; Division of Critical Care Medicine, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Patil V; Division of Critical Care Medicine, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Srinivasan S; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Gollamudi VRM; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Roy Moulik N; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Prasad M; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Narula G; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Banavali S; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
JCO Glob Oncol ; 10: e2300399, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38422460
ABSTRACT

PURPOSE:

To share our clinical experience with the diagnosis and management of children with hematolymphoid malignancies presenting with epilepsia partialis continua (EPC) as a sequelae of measles infection. MATERIALS AND

METHODS:

In December 2022, a series of children in our hemato-oncology unit presented with focal status epilepticus with no conclusive evidence pointing toward any underlying etiology. One such child had a typical measles rash a few weeks before the onset of this focal status epilepticus. After a series of cases with a similar presentation, a clinical pattern suspicious for measles became evident. cerebrospinal fluid polymerase chain reaction was positive for measles virus with measles immunoglobin M detected in the serum. This led to the diagnosis of measles inclusion-body encephalitis in a series of children who presented with EPC over a period of 3 months. EPC is a rare manifestation of measles that is seen only in immunocompromised patients.

RESULTS:

Among the 18 children reported in this series, only 10 had a history of rashes. The rash was mostly transient and elicited only on retrospective history taking. Five of the 18 children who did not lose consciousness during the prolonged seizure episode survived the disease but had residual neurologic sequelae. Among the 18 children, two were unimmunized and immunization status could not be confirmed in three other children.

CONCLUSION:

This case series highlights the threats posed by measles infection in children with cancer who are immunosuppressed because of the underlying disease and ongoing chemotherapy. Loss of herd immunity because of declining measles immunization rates secondary to vaccine hesitancy and COVID-19 lockdown pose a greater risk of measles infection and its complications for patients with deficient immune systems.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia Parcial Contínua / Exantema / Sarampo / Neoplasias Limite: Child / Humans Idioma: En Revista: JCO Glob Oncol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia Parcial Contínua / Exantema / Sarampo / Neoplasias Limite: Child / Humans Idioma: En Revista: JCO Glob Oncol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia