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The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled crossover trial.
Müller, Julian; Titz, Anna; Schneider, Simon R; Bauer, Meret; Mayer, Laura; Lüönd, Lea; Ulrich, Tanja; Furian, Michael; Forrer, Aglaia; Schwarz, Esther I; Bloch, Konrad E; Lichtblau, Mona; Ulrich, Silvia.
Afiliação
  • Müller J; University Hospital of Zurich, Zurich, Switzerland.
  • Titz A; University of Zurich, Zurich, Switzerland.
  • Schneider SR; J. Müller and A. Titz contributed equally to this work.
  • Bauer M; University Hospital of Zurich, Zurich, Switzerland.
  • Mayer L; University of Zurich, Zurich, Switzerland.
  • Lüönd L; J. Müller and A. Titz contributed equally to this work.
  • Ulrich T; University Hospital of Zurich, Zurich, Switzerland.
  • Furian M; University of Zurich, Zurich, Switzerland.
  • Forrer A; University Hospital of Zurich, Zurich, Switzerland.
  • Schwarz EI; University of Zurich, Zurich, Switzerland.
  • Bloch KE; University Hospital of Zurich, Zurich, Switzerland.
  • Lichtblau M; University of Zurich, Zurich, Switzerland.
  • Ulrich S; University Hospital of Zurich, Zurich, Switzerland.
Eur Respir J ; 63(3)2024 Mar.
Article em En | MEDLINE | ID: mdl-38423623
ABSTRACT

BACKGROUND:

Our objective was to investigate the effect of a day-long exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH).

METHODS:

In a randomised controlled crossover trial, stable patients with PAH or distal CTEPH without resting hypoxaemia at low altitude performed two incremental exercise tests to exhaustion one after 3-5 h at high altitude (2500 m) and one at low altitude (470 m).

RESULTS:

In 27 patients with PAH/CTEPH (44% females, mean±sd age 62±14 years), maximal work rate was 110±64 W at 2500 m and 123±64 W at 470 m (-11%, 95% CI -16- -11%; p<0.001). Oxygen saturation measured by pulse oximetry and arterial oxygen tension at end-exercise were 83±6% versus 91±6% and 6.1±1.9 versus 8.6±1.9 kPa (-8% and -29%; both p<0.001) at 2500 versus 470 m, respectively. Maximal oxygen uptake was 17.8±7.5 L·min-1·kg-1 at high altitude versus 20±7.4 L·min-1·kg-1 at low altitude (-11%; p<0.001). At end-exercise, the ventilatory equivalent for carbon dioxide was 43±9 at 2500 m versus 39±9 at 470 m (9%, 95% CI 2-6%; p=0.002). No adverse events occurred during or after exercise.

CONCLUSIONS:

Among predominantly low-risk patients with stable PAH/CTEPH, cycling exercise during the first day at 2500 m was well tolerated, but peak exercise capacity, blood oxygenation and ventilatory efficiency were lower compared with 470 m.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertensão Arterial Pulmonar / Hipertensão Pulmonar Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Respir J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suíça País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertensão Arterial Pulmonar / Hipertensão Pulmonar Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Respir J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suíça País de publicação: Reino Unido